The interplay among psychological distress, the immune system, and brain tumor patient outcomes

Sebastian Otto-Meyer; Jan Lumibao; Eugene Kim; Erik Ladomersky; Lijie Zhai; Kristen L. Lauing; Denise M. Scholtens; Frank Penedo; Christina Amidei; Rimas V. Lukas; Derek A. Wainwright

doi:10.1016/j.cobeha.2019.01.009

The interplay among psychological distress, the immune system, and brain tumor patient outcomes

Sebastian Otto-Meyer, Jan Lumibao, Eugene Kim, Erik Ladomersky, Lijie Zhai, Kristen L. Lauing, Denise M. Scholtens, Frank Penedo, Christina Amidei, Rimas V. Lukas, Derek A. Wainwright

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

A malignant brain tumor diagnosis is often accompanied by intense feelings and can be associated with psychosocial conditions including depression, anxiety, and increased distress levels. Previous work has highlighted the impact of uncontrolled psychological distress among brain tumor patients. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes.

Original language	English (US)
Pages (from-to)	44-50
Number of pages	7
Journal	Current Opinion in Behavioral Sciences
Volume	28
DOIs	https://doi.org/10.1016/j.cobeha.2019.01.009
State	Published - Aug 2019

ASJC Scopus subject areas

Cognitive Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

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Otto-Meyer, Sebastian ; Lumibao, Jan ; Kim, Eugene ; Ladomersky, Erik ; Zhai, Lijie ; Lauing, Kristen L. ; Scholtens, Denise M. ; Penedo, Frank ; Amidei, Christina ; Lukas, Rimas V. ; Wainwright, Derek A. / The interplay among psychological distress, the immune system, and brain tumor patient outcomes. In: Current Opinion in Behavioral Sciences. 2019 ; Vol. 28. pp. 44-50.

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abstract = "A malignant brain tumor diagnosis is often accompanied by intense feelings and can be associated with psychosocial conditions including depression, anxiety, and increased distress levels. Previous work has highlighted the impact of uncontrolled psychological distress among brain tumor patients. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes.",

author = "Sebastian Otto-Meyer and Jan Lumibao and Eugene Kim and Erik Ladomersky and Lijie Zhai and Lauing, {Kristen L.} and Scholtens, {Denise M.} and Frank Penedo and Christina Amidei and Lukas, {Rimas V.} and Wainwright, {Derek A.}",

note = "Funding Information: This work was supported by NIH grants R00 NS082381 (D.A.W.), R01 NS097851-01 (D.A.W.), P50 CA221747 Project 2 (D.A.W. and R.V.L.), and T32 CA070085 (E.L.). ",

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The interplay among psychological distress, the immune system, and brain tumor patient outcomes. / Otto-Meyer, Sebastian; Lumibao, Jan; Kim, Eugene; Ladomersky, Erik; Zhai, Lijie; Lauing, Kristen L.; Scholtens, Denise M.; Penedo, Frank; Amidei, Christina ; Lukas, Rimas V.; Wainwright, Derek A.

In: Current Opinion in Behavioral Sciences, Vol. 28, 08.2019, p. 44-50.

Research output: Contribution to journal › Review article › peer-review

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AU - Otto-Meyer, Sebastian

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AU - Kim, Eugene

AU - Ladomersky, Erik

AU - Zhai, Lijie

AU - Lauing, Kristen L.

AU - Scholtens, Denise M.

AU - Penedo, Frank

AU - Amidei, Christina

AU - Lukas, Rimas V.

AU - Wainwright, Derek A.

N1 - Funding Information: This work was supported by NIH grants R00 NS082381 (D.A.W.), R01 NS097851-01 (D.A.W.), P50 CA221747 Project 2 (D.A.W. and R.V.L.), and T32 CA070085 (E.L.).

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N2 - A malignant brain tumor diagnosis is often accompanied by intense feelings and can be associated with psychosocial conditions including depression, anxiety, and increased distress levels. Previous work has highlighted the impact of uncontrolled psychological distress among brain tumor patients. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes.

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