TY - JOUR
T1 - The interplay among psychological distress, the immune system, and brain tumor patient outcomes
AU - Otto-Meyer, Sebastian
AU - Lumibao, Jan
AU - Kim, Eugene
AU - Ladomersky, Erik
AU - Zhai, Lijie
AU - Lauing, Kristen L.
AU - Scholtens, Denise M.
AU - Penedo, Frank
AU - Amidei, Christina
AU - Lukas, Rimas V.
AU - Wainwright, Derek A.
N1 - Funding Information:
This work was supported by NIH grants R00 NS082381 (D.A.W.), R01 NS097851-01 (D.A.W.), P50 CA221747 Project 2 (D.A.W. and R.V.L.), and T32 CA070085 (E.L.).
PY - 2019/8
Y1 - 2019/8
N2 - A malignant brain tumor diagnosis is often accompanied by intense feelings and can be associated with psychosocial conditions including depression, anxiety, and increased distress levels. Previous work has highlighted the impact of uncontrolled psychological distress among brain tumor patients. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes.
AB - A malignant brain tumor diagnosis is often accompanied by intense feelings and can be associated with psychosocial conditions including depression, anxiety, and increased distress levels. Previous work has highlighted the impact of uncontrolled psychological distress among brain tumor patients. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes.
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U2 - 10.1016/j.cobeha.2019.01.009
DO - 10.1016/j.cobeha.2019.01.009
M3 - Review article
C2 - 31049368
AN - SCOPUS:85062004138
VL - 28
SP - 44
EP - 50
JO - Current Opinion in Behavioral Sciences
JF - Current Opinion in Behavioral Sciences
SN - 2352-1546
ER -