The interplay among psychological distress, the immune system, and brain tumor patient outcomes

Sebastian Otto-Meyer, Jan Lumibao, Eugene Kim, Erik Ladomersky, Lijie Zhai, Kristen L. Lauing, Denise M. Scholtens, Frank J Penedo, Christina Amidei, Rimas V. Lukas, Derek A. Wainwright

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

A malignant brain tumor diagnosis is often accompanied by intense feelings and can be associated with psychosocial conditions including depression, anxiety, and increased distress levels. Previous work has highlighted the impact of uncontrolled psychological distress among brain tumor patients. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalCurrent Opinion in Behavioral Sciences
Volume28
DOIs
StatePublished - Aug 2019

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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