The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop

Gr Scott Budinger*, Ronald A. Kohanski, Weiniu Gan, Michael S. Kobor, Luis A. Amaral, Mary Armanios, Karl T. Kelsey, Annie Pardo, Rubin Tuder, Fernando Macian, Navdeep Chandel, Douglas Vaughan, Mauricio Rojas, Ana L. Mora, Elizabeth Kovacs, Steven R. Duncan, Toren Finkel, Augustine Choi, Oliver Eickelberg, Danica ChenAlvar Agusti, Moises Selman, William E. Balch, Paula Busse, Anning Lin, Richard Morimoto, Jacob I. Sznajder, Victor J. Thannickal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Death from chronic lung disease is increasing and chronic obstructive pulmonary disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately affect elderly individuals, making it likely that these diseases will become more frequent and severe as the worldwide population ages. Chronic lung diseases are associated with substantial morbidity, frequently resulting in exercise limiting dyspnea, immobilization, and isolation. Therefore, effective strategies to prevent or treat lung disease are likely to increase healthspan as well as life span. This review summarizes the findings of a joint workshop sponsored by the NIA and NHLBI that brought together investigators focused on aging and lung biology. These investigators encouraged the use of genetic systems and aged animals in the study of lung disease and the development of integrative systems-based platforms that can dynamically incorporate data sets that describe the genomics, transcriptomics, epigenomics, metabolomics, and proteomics of the aging lung in health and disease. Further research was recommended to integrate benchmark biological hallmarks of aging in the lung with the pathobiology of acute and chronic lung diseases with divergent pathologies for which advanced age is the most important risk factor.

Original languageEnglish (US)
Pages (from-to)1492-1500
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume72
Issue number11
DOIs
StatePublished - Nov 1 2017

Funding

1Feinberg School of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois. 2Division of Aging Biology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland. 3Division of Lung Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland. 4Center for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada. 5Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois. 6Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. 7Departments of Epidemiology, Laboratory Medicine & Pathology, Brown University, Providence, Rhode Island. 8Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México. 9Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver Health Sciences Center, Denver, Colorado. 10Department of Pathology, Albert Einstein College of Medicine, Bronx, New York. 11Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 12Department of Surgery, University of Colorado at Denver Health Sciences Center, Denver, Colorado. 13University of Alabama at Birmingham, Birmingham, Alabama. 14Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland. 15Weill Cornell Medical College, Division of Pulmonary and Critical Care Medicine, Weill Department of Medicine, New York, New York. 16Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus. 17Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, California. 18Respiratory Institute, Hospital Clinic, IDIBAPS, University of Barcelona, CIBERES, Spain. 19Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México. 20Department of Chemical Physiology, Department of Cell and Molecular Biology, The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California. 21Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, New York. 22Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois. 23Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois.

Keywords

  • Age-related pathology
  • Biology of aging
  • Lungs/pulmonary

ASJC Scopus subject areas

  • General Medicine

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