The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index

Fabio Efficace*, Francesco Cottone, Laura B. Oswald, David Cella, Andrea Patriarca, Pasquale Niscola, Massimo Breccia, Uwe Platzbecker, Giuseppe A. Palumbo, Giovanni Caocci, Reinhard Stauder, Alessandra Ricco, Duska Petranovic, Jo Caers, Mario Luppi, Luana Fianchi, Chiara Frairia, Isabella Capodanno, Elena Follini, Chiara SarloPaola Fazi, Marco Vignetti

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We aimed to compare fatigue of newly diagnosed patients with myelodysplastic syndromes (MDS) with that of the general population (GP). We also investigated the ability of the IPSS and IPSS-R to capture severity of patient-reported fatigue at diagnostic workup. A sample of 927 newly diagnosed patients with MDS was consecutively enrolled in a large international observational study and all patients completed the FACIT-Fatigue questionnaire at baseline. Fatigue was compared with that of the GP (N = 1075) and a 3-point difference in mean scores was considered as clinically meaningful. Fatigue of MDS patients was on average 4.6 points below the mean of the GP (95% CI, −5.9 to −3.2, p < 0.001), reflecting clinically meaningful worse fatigue. Unlike the IPSS, the IPSS-R identified clearly distinct subgroups with regard to burden of fatigue. Mean scores differences compared with GP ranged from nonclinically relevant for very low risk (Δ = −1.8, 95% CI, −4.0 to 0.5, p = 0.119) to large clinically meaningful differences for very high-risk IPSS-R patients (Δ = −8.2, 95% CI, −10.3 to −6.2, p < 0.001). At diagnostic workup, fatigue of MDS is clinically meaningful worse than that reported by the GP. Compared with the IPSS classification, the IPSS-R provides a better stratification of patients with regard to fatigue severity.

Original languageEnglish (US)
Pages (from-to)2451-2459
Number of pages9
JournalLeukemia
Volume34
Issue number9
DOIs
StatePublished - Sep 1 2020

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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