The JAK-STAT pathway at 30: Much learned, much more to do

Rachael L. Philips, Yuxin Wang, Hyeon Joo Cheon, Yuka Kanno, Massimo Gadina, Vittorio Sartorelli, Curt M. Horvath, James E. Darnell, George R. Stark, John J. O'Shea*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals. These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors. This knowledge has provided numerous insights into human disease, from immune deficiencies to cancer, and was rapidly translated to new drugs for autoimmune, allergic, and infectious diseases, including COVID-19. Despite these advances, major challenges and opportunities remain.

Original languageEnglish (US)
Pages (from-to)3857-3876
Number of pages20
Issue number21
StatePublished - Oct 13 2022

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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