The Jak-STAT pathway stimulated by interferon alpha or interferon beta.

Curt M Horvath*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Type I interferons, such as interferon alpha and interferon beta (IFN-alpha and beta), signal through a Janus kinase (Jak) to signal transduction and activator of transcription (STAT) pathway to stimulate gene expression. In response to ligand binding, the receptors dimerize, Jaks phosphorylate STAT1 and STAT2, which then dimerize and interact with a third transcriptional regulator IFN regulatory factor 9 (IRF9) to stimulate gene expression. IFN-alpha is the main innate antiviral cytokine and is essential for effective immune response to viral infection. The animation shows activation of STAT-responsive gene expression in response to type I IFNs.

Original languageEnglish (US)
JournalScience's STKE : signal transduction knowledge environment
Issue number260
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Medicine(all)


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