The JARID2-PRC2 duality

Hans Martin Herz, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Polycomb group proteins (PcG) are required for proper developmental regulation and cell fate commitment in metazoans. Recently, four studies reported the identification of JARID2, a JmjC domain-containing protein, as a component of the Polycomb-repressive complex 2 (PRC2), which is involved in implementing histone H3 Lys 27 methylation and transcriptional repression during development. Here, we discuss the implications of these studies for an improved understanding of PcG function in development.

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
JournalGenes and Development
Volume24
Issue number9
DOIs
StatePublished - May 1 2010

Keywords

  • Chromatin
  • Histone methylation
  • Jarid2
  • Polycomb

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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