The journey of the organelle: Teamwork and regulation in intracellular transport

Kari Barlan, Molly J. Rossow, Vladimir I. Gelfand*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Specific subsets of biochemical reactions in eukaryotic cells are restricted to individual membrane compartments, or organelles. Cells, therefore, face the monumental task of moving the products of those reactions between individual organelles. Because of the high density of the cytoplasm and the large size of membrane organelles, simple diffusion is grossly insufficient for this task. Proper trafficking between membrane organelles thus relies on cytoskeletal elements and the activity of motor proteins, that act both in transport of membrane compartments and as tethering agents to ensure their proper distribution and to facilitate organelle interactions.

Original languageEnglish (US)
Pages (from-to)483-488
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume25
Issue number4
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Cell Biology

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