The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation

Qiao Zhang, Hong Kuang, Cong Chen, Jie Yan, Hanh Chi Do-Umehara, Xin Yuan Liu, Laura Dada, Karen M. Ridge, Navdeep S. Chandel, Jing Liu*

*Corresponding author for this work

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Mitophagy is essential for cellular homeostasis, but how mitophagy is regulated is largely unknown. Here we found that the kinase Jnk2 was required for stress-induced mitophagy. Jnk2 promoted ubiquitination and proteasomal degradation of the small mitochondrial form of the tumor suppressor ARF (smARF). Loss of Jnk2 led to the accumulation of smARF, which induced excessive autophagy that resulted in lysosomal degradation of the mitophagy adaptor p62 at steady state. Depletion of p62 prevented Jnk2-deficient cells from mounting mitophagy upon stress. Jnk2-deficient mice displayed defective mitophagy, which resulted in tissue damage under hypoxic stress, as well as hyperactivation of inflammasomes and increased mortality in sepsis. Our findings define a unique mechanism of maintaining immunological homeostasis that protects the host from tissue damage and mortality.

Original languageEnglish (US)
Pages (from-to)458-466
Number of pages9
JournalNature Immunology
Volume16
Issue number5
DOIs
StatePublished - May 28 2015

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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