The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus

Indira M. Raman*, Laurence O. Trussell

*Corresponding author for this work

Research output: Contribution to journalArticle

183 Scopus citations

Abstract

Neurons in the nucleus magnocellularis (nMAG) of the chicken precisely transmit auditory nerve activity via glutamatergic synapses. Using techniques for rapid application of solutions, we have explored the properties of CNQX-sensitive glutamate receptors in whole cells and outside-out patches from the nMAG. Glutamate-evoked current in patches desensitized biphasically to less than 1% of the peak current, with a fast time constant of 960 μs at 22°C, decreasing to 570 μs at 33°C. Dose-response studies using kainate indicated that at least two agonist molecules bind to gate the channel. We propose a kinetic model that quantitatively describes our experimental observations. The rapid kinetics of this receptor are well suited to allow phase locking of synaptic signals to auditory stimuli.

Original languageEnglish (US)
Pages (from-to)173-186
Number of pages14
JournalNeuron
Volume9
Issue number1
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Neuroscience(all)

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