The laboratory domestication of Caenorhabditis elegans

Mark G. Sterken, L. Basten Snoek, Jan E. Kammenga*, Erik C. Andersen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Model organisms are of great importance to our understanding of basic biology and to making advances in biomedical research. However, the influence of laboratory cultivation on these organisms is underappreciated, and especially how that environment can affect research outcomes. Recent experiments led to insights into how the widely used laboratory reference strain of the nematode Caenorhabditis elegans compares with natural strains. Here we describe potential selective pressures that led to the fixation of laboratory-derived alleles for the genes npr-1, glb-5, and nath-10. These alleles influence a large number of traits, resulting in behaviors that affect experimental interpretations. Furthermore, strong phenotypic effects caused by these laboratory-derived alleles hinder the discovery of natural alleles. We highlight strategies to reduce the influence of laboratory-derived alleles and to harness the full power of C. elegans.

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalTrends in Genetics
Volume31
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • Aerotaxis
  • Caenorhabditis elegans
  • Laboratory derived
  • Npr-1
  • Selection

ASJC Scopus subject areas

  • Genetics

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