Four children with deficient thymus-dependent lymphocytes and normal parathyroid function are described. They had normal immunoglobulin levels and responded to antigenic stimulation. Delayed skin tests were negative and in vitro lymphocyte responses to PHA, C. albicans, and streptococcal M protein were deficient. Infections with C. albicans (three patients), atypical mycobacteria (two patients), and P. carinii (one patient) were documented. Treatment with transfer factor did not alter their clinical or laboratory findings. It is postulated that these patients presented a spectrum of thymic deficiency and that transfer factor was ineffective because of the absence of thymus-influenced lymphocytes.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health