The lack of effect of transfer factor in thymic dysplasia with immunoglobulin synthesis

Lauren M Pachman*, Charles H. Kirkpatrick, Donald H. Kaufman, Richard M. Rothberg

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Four children with deficient thymus-dependent lymphocytes and normal parathyroid function are described. They had normal immunoglobulin levels and responded to antigenic stimulation. Delayed skin tests were negative and in vitro lymphocyte responses to PHA, C. albicans, and streptococcal M protein were deficient. Infections with C. albicans (three patients), atypical mycobacteria (two patients), and P. carinii (one patient) were documented. Treatment with transfer factor did not alter their clinical or laboratory findings. It is postulated that these patients presented a spectrum of thymic deficiency and that transfer factor was ineffective because of the absence of thymus-influenced lymphocytes.

Original languageEnglish (US)
Pages (from-to)681-688
Number of pages8
JournalThe Journal of pediatrics
Volume84
Issue number5
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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