The Language of Histone Crosstalk

Jung Shin Lee; Edwin Smith; Ali Shilatifard

doi:10.1016/j.cell.2010.08.011

The Language of Histone Crosstalk

Jung Shin Lee, Edwin Smith, Ali Shilatifard^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

470 Scopus citations

Abstract

It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.

Original language	English (US)
Pages (from-to)	682-685
Number of pages	4
Journal	Cell
Volume	142
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2010.08.011
State	Published - Sep 3 2010

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2010.08.011

Cite this

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title = "The Language of Histone Crosstalk",

abstract = "It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.",

author = "Lee, {Jung Shin} and Edwin Smith and Ali Shilatifard",

note = "Funding Information: We thank Dr. E. Park for the critical reading of the manuscript. We also thank L. Shilatifard for editorial assistance. Studies in the Shilatifard laboratory are supported in part by grants from the NIH: R01CA89455, R01GM069905, and R01CA150265.",

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AU - Smith, Edwin

AU - Shilatifard, Ali

N1 - Funding Information: We thank Dr. E. Park for the critical reading of the manuscript. We also thank L. Shilatifard for editorial assistance. Studies in the Shilatifard laboratory are supported in part by grants from the NIH: R01CA89455, R01GM069905, and R01CA150265.

PY - 2010/9/3

Y1 - 2010/9/3

N2 - It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.

AB - It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.

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M3 - Short survey

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The Language of Histone Crosstalk

Abstract

ASJC Scopus subject areas

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