The large vestibular aqueduct syndrome.

G. E. Valvassori*, J. D. Clemis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

453 Scopus citations


The radiographic observation of 50 patients, each having an enlarged (greater than 1.5 mm. diameter) vestibular aqueduct, are analyzed. In addition to the aqueduct other associated inner ear anomalies have been identified in 60% of this population including: enlarged vestibule (14); enlarged vestibule and lateral semicircular canal (7); enlarged vestibule and hypoplastic cochlea (4); and hypoplastic cochlea (4). The large equeduct then presumably represents an arrested phase of inner ear development common to all 50 cases. Only 8 of these cases may fall into the Mondini or Mondini-Alexander classification wherein cochlear abnormalities have been identified. The size of the aqueduct ranged from 1.5 to 8 mm. in the anteroposterior diameter; the clinical incidence is 50 in 3700 consecutive cases referred for inner ear tomography. Bilateral involvement is twice as common as unilateral with a female to male predominance of 3:2. Most cases are associated with congenital hearing losses.

Original languageEnglish (US)
Pages (from-to)723-728
Number of pages6
JournalThe Laryngoscope
Issue number5
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Otorhinolaryngology


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