The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells

Miriam A. Calenoff, Cyrus S. Badshah, Mauro C. Dal Canto, Howard L. Lipton, M. Kathleen Rundell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

Original languageEnglish (US)
Pages (from-to)5544-5549
Number of pages6
JournalJournal of virology
Volume69
Issue number9
DOIs
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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