The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells

Miriam A. Calenoff; Cyrus S. Badshah; Mauro C. Dal Canto; Howard L. Lipton; M. Kathleen Rundell

doi:10.1128/jvi.69.9.5544-5549.1995

The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells

Miriam A. Calenoff, Cyrus S. Badshah, Mauro C. Dal Canto, Howard L. Lipton, M. Kathleen Rundell^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

Original language	English (US)
Pages (from-to)	5544-5549
Number of pages	6
Journal	Journal of virology
Volume	69
Issue number	9
DOIs	https://doi.org/10.1128/jvi.69.9.5544-5549.1995
State	Published - Sep 1995
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.69.9.5544-5549.1995

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abstract = "A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.",

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AU - Calenoff, Miriam A.

AU - Badshah, Cyrus S.

AU - Dal Canto, Mauro C.

AU - Lipton, Howard L.

AU - Rundell, M. Kathleen

PY - 1995/9

Y1 - 1995/9

N2 - A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

AB - A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

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IS - 9

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The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells

Abstract

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