The left inferior frontal gyrus is crucial for reading the mind in the eyes: Brain lesion evidence

Olga Dal Monte, Selene Schintu, Matteo Pardini, Anna Berti, Eric M. Wassermann, Jordan Henry Grafman, Frank Krueger*

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Deficit in the ability to understand and predict the mental states of others is one of the central features of traumatic brain injury (TBI), leading to problems in social-daily life such as social withdrawal and the inability to maintain work or family relationships. Although several functional neuroimaging studies have identified a widely distributed brain network involved in the Reading the Mind in the Eyes Test (RMET), the necessary brain regions engaged in this capacity are still heavily debated. In this study, we combined the RMET with a whole-brain voxel-based lesion symptom mapping (VLSM) approach to identify brain regions necessary for adequate RMET performance in a large sample of patients with penetrating TBI (pTBI). Our results revealed that pTBI patients performed worse on the RMET compared to non-head injured controls, and impaired RMET performance was associated with lesions in the left inferior frontal gyrus (IFG). Our findings suggest that the left IFG is a key region in reading the mind in the eyes, probably involved in a more general impairment of a semantic working memory system that facilitates reasoning about what others are feeling and thinking as expressed by the eyes.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalCortex
Volume58
DOIs
StatePublished - Jan 1 2014

Fingerprint

Prefrontal Cortex
Reading
Brain
Penetrating Head Injuries
Functional Neuroimaging
Aptitude
Family Relations
Social Problems
Short-Term Memory
Semantics
Emotions

Keywords

  • Mental states
  • RMET
  • Semantic working memory
  • Traumatic brain injury
  • Voxel-based lesion symptom mapping

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

Dal Monte, Olga ; Schintu, Selene ; Pardini, Matteo ; Berti, Anna ; Wassermann, Eric M. ; Grafman, Jordan Henry ; Krueger, Frank. / The left inferior frontal gyrus is crucial for reading the mind in the eyes : Brain lesion evidence. In: Cortex. 2014 ; Vol. 58. pp. 9-17.
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The left inferior frontal gyrus is crucial for reading the mind in the eyes : Brain lesion evidence. / Dal Monte, Olga; Schintu, Selene; Pardini, Matteo; Berti, Anna; Wassermann, Eric M.; Grafman, Jordan Henry; Krueger, Frank.

In: Cortex, Vol. 58, 01.01.2014, p. 9-17.

Research output: Contribution to journalArticle

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