The life cycle of human papillomaviruses

Cary A. Moody, Laimonis A. Laimins*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The life cycle of human papillomaviruses (HPV) is dependent on epithelial differentiation and is regulated by a number of cellular proteins. HPVs infect keratinocytes in the basal layer of the epithelium, and upon cell division, one daughter cell migrates to upper layers while undergoing differentiation. Differentiation triggers the productive phase of the viral life cycle, including viral DNA amplification, late gene expression and virion assembly. Through the actions of viral proteins, infected cells remain active in the cell cycle, creating an environment conducive to late viral events and the production of progeny virions.

Original languageEnglish (US)
Title of host publicationDNA Tumor Viruses
PublisherSpringer US
Pages75-104
Number of pages30
ISBN (Electronic)9780387689456
ISBN (Print)9780387689449
DOIs
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Medicine(all)

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