The little elongation complex functions at initiation and elongation phases of snRNA gene transcription

Deqing Hu, EdwinR Smith, AlexanderS Garruss, Nima Mohaghegh, JosephM Varberg, Chengqi Lin, Jessica Jackson, Xin Gao, Anita Saraf, Laurence Florens, MichaelP Washburn, JoelC Eissenberg, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their promoter structure, selectivity for either RNA polymerase (Pol) II or III, and because of their unique mechanism of termination that is tightly linked with the promoter. Recently, we identified the little elongation complex (LEC) in Drosophila that is required for the expression of Pol II-transcribed snRNA genes. Here, using Drosophila and mammalian systems, we provide genetic and molecular evidence that LEC functions in at least two phases of snRNA transcription: an initiation step requiring the ICE1 subunit, and an elongation step requiring ELL.

Original languageEnglish (US)
Pages (from-to)493-505
Number of pages13
JournalMolecular cell
Volume51
Issue number4
DOIs
StatePublished - Aug 22 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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