"The little engine that could": Voltage-dependent Na+ channels and the subthalamic nucleus

D. James Surmeier; Mark D. Bevan

doi:10.1016/S0896-6273(03)00400-8

"The little engine that could": Voltage-dependent Na⁺ channels and the subthalamic nucleus

D. James Surmeier^*, Mark D. Bevan

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The most effective treatment for late-stage Parkinson's disease is to electrically stimulate the subthalamic nucleus (STN) at high frequencies. Why this strategy works is unclear. The work by Do and Bean shows that the Na channels in STN neurons have distinctive features - like resurgence - that regulate their spiking behavior, providing new insights into the mechanism of DBS.

Original language	English (US)
Pages (from-to)	5-6
Number of pages	2
Journal	Neuron
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/S0896-6273(03)00400-8
State	Published - Jul 3 2003

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0896-6273(03)00400-8

Cite this

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abstract = "The most effective treatment for late-stage Parkinson's disease is to electrically stimulate the subthalamic nucleus (STN) at high frequencies. Why this strategy works is unclear. The work by Do and Bean shows that the Na channels in STN neurons have distinctive features - like resurgence - that regulate their spiking behavior, providing new insights into the mechanism of DBS.",

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AB - The most effective treatment for late-stage Parkinson's disease is to electrically stimulate the subthalamic nucleus (STN) at high frequencies. Why this strategy works is unclear. The work by Do and Bean shows that the Na channels in STN neurons have distinctive features - like resurgence - that regulate their spiking behavior, providing new insights into the mechanism of DBS.

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"The little engine that could": Voltage-dependent Na⁺ channels and the subthalamic nucleus

Abstract

ASJC Scopus subject areas

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