The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

W. K. Chung, A. Luke, R. S. Cooper, C. Rotini, A. Vidal-Puig, M. Rosenbaum, D. Gordon, S. M. Leal, S. Caprio, R. Goldsmith, A. L. Andreu, C. Bruno, S. DiMauro, M. Heo, W. L. Lowe, B. B. Lowell, D. B. Allison, R. L. Leibel*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

Original languageEnglish (US)
Pages (from-to)S49-S50
JournalInternational Journal of Obesity
Volume23
DOIs
StatePublished - Jun 1 1999

Keywords

  • Diabetes
  • Obesity
  • Skeletal muscle
  • Thermogenesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Gordon, D., Leal, S. M., Caprio, S., Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B., & Leibel, R. L. (1999). The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis. International Journal of Obesity, 23, S49-S50. https://doi.org/10.1038/sj.ijo.0800945