The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

W. K. Chung; A. Luke; R. S. Cooper; C. Rotini; A. Vidal-Puig; M. Rosenbaum; D. Gordon; S. M. Leal; S. Caprio; R. Goldsmith; A. L. Andreu; C. Bruno; S. DiMauro; M. Heo; W. L. Lowe; B. B. Lowell; D. B. Allison; R. L. Leibel

doi:10.1038/sj.ijo.0800945

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

W. K. Chung, A. Luke, R. S. Cooper, C. Rotini, A. Vidal-Puig, M. Rosenbaum, D. Gordon, S. M. Leal, S. Caprio, R. Goldsmith, A. L. Andreu, C. Bruno, S. DiMauro, M. Heo, W. L. Lowe, B. B. Lowell, D. B. Allison, R. L. Leibel^*

^*Corresponding author for this work

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Abstract

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

Original language	English (US)
Pages (from-to)	S49-S50
Journal	International Journal of Obesity
Volume	23
DOIs	https://doi.org/10.1038/sj.ijo.0800945
State	Published - Jun 1 1999

Keywords

Diabetes
Obesity
Skeletal muscle
Thermogenesis

ASJC Scopus subject areas

Nutrition and Dietetics
Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.ijo.0800945

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Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Gordon, D., Leal, S. M., Caprio, S., Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B., & Leibel, R. L. (1999). The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis. International Journal of Obesity, 23, S49-S50. https://doi.org/10.1038/sj.ijo.0800945

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title = "The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis",

abstract = "The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.",

keywords = "Diabetes, Obesity, Skeletal muscle, Thermogenesis",

author = "Chung, {W. K.} and A. Luke and Cooper, {R. S.} and C. Rotini and A. Vidal-Puig and M. Rosenbaum and D. Gordon and Leal, {S. M.} and S. Caprio and R. Goldsmith and Andreu, {A. L.} and C. Bruno and S. DiMauro and M. Heo and Lowe, {W. L.} and Lowell, {B. B.} and Allison, {D. B.} and Leibel, {R. L.}",

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month = jun,

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doi = "10.1038/sj.ijo.0800945",

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Chung, WK, Luke, A, Cooper, RS, Rotini, C, Vidal-Puig, A, Rosenbaum, M, Gordon, D, Leal, SM, Caprio, S, Goldsmith, R, Andreu, AL, Bruno, C, DiMauro, S, Heo, M, Lowe, WL, Lowell, BB, Allison, DB & Leibel, RL 1999, 'The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis', International Journal of Obesity, vol. 23, pp. S49-S50. https://doi.org/10.1038/sj.ijo.0800945

TY - JOUR

T1 - The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

AU - Chung, W. K.

AU - Luke, A.

AU - Cooper, R. S.

AU - Rotini, C.

AU - Vidal-Puig, A.

AU - Rosenbaum, M.

AU - Gordon, D.

AU - Leal, S. M.

AU - Caprio, S.

AU - Goldsmith, R.

AU - Andreu, A. L.

AU - Bruno, C.

AU - DiMauro, S.

AU - Heo, M.

AU - Lowe, W. L.

AU - Lowell, B. B.

AU - Allison, D. B.

AU - Leibel, R. L.

PY - 1999/6/1

Y1 - 1999/6/1

N2 - The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

AB - The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

KW - Diabetes

KW - Obesity

KW - Skeletal muscle

KW - Thermogenesis

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DO - 10.1038/sj.ijo.0800945

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C2 - 10454123

AN - SCOPUS:0033002467

SN - 0307-0565

VL - 23

SP - S49-S50

JO - International Journal of Obesity

JF - International Journal of Obesity

ER -

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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