The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

Guillermo Oliver; Jonathan Kipnis; Gwendalyn J. Randolph; Natasha L. Harvey

doi:10.1016/j.cell.2020.06.039

The Lymphatic Vasculature in the 21^st Century: Novel Functional Roles in Homeostasis and Disease

Guillermo Oliver^*, Jonathan Kipnis, Gwendalyn J. Randolph, Natasha L. Harvey

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Review article › peer-review

447 Scopus citations

Abstract

Oliver et al. comprehensively review the anatomy, development, and functional roles of the lymphatic vasculature in health and disease. They highlight emerging evidence suggesting that the lymphatic system plays more diverse physiological roles that previously appreciated.

Original language	English (US)
Pages (from-to)	270-296
Number of pages	27
Journal	Cell
Volume	182
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2020.06.039
State	Published - Jul 23 2020

Funding

We want to thank Justin Rustenhoven, Kelly Betterman, and Nozomu Takata for help with some of the drawings included in the figures. This work was partially supported by NIH RO1HL073402-16 (to G.O.); NIH RF1 AG 057496 (to J.K.); NIH R37 AI 049653 , DP1 DK109668 , and R01DK119147 and a Rainin Foundation Synergy Award (to G.J.R.), and NHMRC APP1146800 and APP1146352 (to N.L.H.).

Keywords

Alzheimer's
Crohn's disease
Lymphatics
Parkinson's
cardiovascular
glaucoma
immunity
inflammation
lymphatic function
lymphatic vasculature
lymphedema
myocardial infarction
neurological disease
obesity
tumors

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cell.2020.06.039

Cite this

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title = "The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease",

abstract = "Oliver et al. comprehensively review the anatomy, development, and functional roles of the lymphatic vasculature in health and disease. They highlight emerging evidence suggesting that the lymphatic system plays more diverse physiological roles that previously appreciated.",

keywords = "Alzheimer's, Crohn's disease, Lymphatics, Parkinson's, cardiovascular, glaucoma, immunity, inflammation, lymphatic function, lymphatic vasculature, lymphedema, myocardial infarction, neurological disease, obesity, tumors",

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