The lymphatic vasculature: Recent progress and paradigms

Guillermo Oliver*, Kari Alitalo

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

182 Scopus citations


The field of lymphatic research has been recently invigorated by the identification of genes and mechanisms that control various aspects of lymphatic development. We are beginning to understand how, starting from a subgroup of embryonic venous endothelial cells, the whole lymphatic system forms in a stepwise manner. The generation of genetically engineered mice with defects in different steps of the lymphangiogenic program has provided models that are increasing our understanding of the lymphatic system in health and disease. This knowledge, in turn, should lead to the development of better diagnostic methods and treatments of lymphatic disorders and tumor metastasis.

Original languageEnglish (US)
Pages (from-to)457-483
Number of pages27
JournalAnnual Review of Cell and Developmental Biology
StatePublished - Dec 12 2005


  • Lymphangiogenesis
  • Lymphatic development
  • Lymphedema
  • Tumor metastasis

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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