The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites

Mariana De Niz, Ann Katrin Ullrich, Arlett Heiber, Alexandra Blancke Soares, Christian Pick, Ruth Lyck, Derya Keller, Gesine Kaiser, Monica Prado, Sven Flemming, Hernando Del Portillo, Chris J. Janse, Volker Heussler*, Tobias Spielmann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 and MAHRP1. Red blood cells infected with P. berghei parasites lacking SBP1 or MAHRP1a fail to bind the endothelial receptor CD36 and show reduced sequestration and virulence in mice. Complementation of the mutant P. berghei parasites with the respective P. falciparum SBP1 and MAHRP1 orthologues restores sequestration and virulence. These findings reveal evolutionary conservation of the machinery underlying sequestration of divergent malaria parasites and support the notion that the P. berghei rodent model is an adequate tool for research on malaria virulence.

Original languageEnglish (US)
Article number11659
JournalNature communications
Volume7
DOIs
StatePublished - May 26 2016

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy

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