The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex

Michael L. LaCroix-Fralish, Maria D. Rutkowski, James Neil Weinstein, Jeffrey S. Mogil, Joyce A. DeLeo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Study Design. This study examined the differences in tactile hypersensitivity across 6 different strains of male mice, and between male and female rats of 3 different strains in a rodent model of low back pain associated with lumbar radiculopathy. Objective. We investigated the possibility that differences in tactile allodynia following the same nerve root injury are affected by genotype and sex in rodents. Summary of Background Data. Low back pain associated with radiculopathy affects countless people throughout the world, encompassing a wide range of individual pain susceptibility. The roles of genetics and sex on differences in nociceptive sensitivities following lumbar nerve root injury have yet to be fully characterized. Methods, Six strains of mice (BALB/cJ, CBA/J, C57BL/ 6J, 129P3/J, C3H/HeJ, and C58/J; all males) and male and female Sprague Dawley, Holtzman, and Long-Evans rats underwent a lumbar nerve root injury followed by assessment of tactile allodynia. Results. The most sensitive mouse strains following nerve root injury were: 129P3/J, C58/J, and BALB/cJ; and the less sensitive strains were: C57BL/6J, C3H/HeJ, and CBA/J. Female Sprague Dawley and Long-Evans rats displayed increased hypersensitivity following nerve root injury compared to males. No sex differences were observed in Holtzman rats. Conclusions. Different mouse strains, and male and female rats that are exposed to identical nerve root injuries have diverse levels of tactile hypersensitivity, supporting the hypothesis that genetic factors and sex play a key role in radicular pain. Our results correlate with data compiled in identical mouse and rat strains after L5-L6 nerve ligation, suggesting that the precise nature of the injury is not relevant to the inheritance of neuropathic symptom sensitivity.

Original languageEnglish (US)
Pages (from-to)1821-1827
Number of pages7
JournalSpine
Volume30
Issue number16
DOIs
StatePublished - Aug 15 2005

Keywords

  • Genetics
  • Low back pain
  • Radicular pain
  • Sex differences

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex'. Together they form a unique fingerprint.

Cite this