TY - JOUR
T1 - The many faces of filamin
T2 - A versatile molecular scaffold for cell motility and signalling
AU - Feng, Yuanyi
AU - Walsh, Christopher A.
PY - 2004/11
Y1 - 2004/11
N2 - Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.
AB - Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.
UR - http://www.scopus.com/inward/record.url?scp=7944237936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7944237936&partnerID=8YFLogxK
U2 - 10.1038/ncb1104-1034
DO - 10.1038/ncb1104-1034
M3 - Review article
C2 - 15516996
AN - SCOPUS:7944237936
SN - 1465-7392
VL - 6
SP - 1034
EP - 1038
JO - Nature Cell Biology
JF - Nature Cell Biology
IS - 11
ER -
