The many faces of filamin: A versatile molecular scaffold for cell motility and signalling

Yuanyi Feng, Christopher A. Walsh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

382 Scopus citations

Abstract

Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.

Original languageEnglish (US)
Pages (from-to)1034-1038
Number of pages5
JournalNature Cell Biology
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2004

ASJC Scopus subject areas

  • Cell Biology

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