The MAPP research network

A novel study of urologic chronic pelvic pain syndromes

The MAPP Research Network Study Group

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Trial registration. ClinicalTrials.gov identifier: NCT01098279 "Chronic Pelvic Pain Study of Individuals with Diagnoses or Symptoms of Interstitial Cystitis and/or Chronic Prostatitis (MAPP-EP)".

Urologic chronic pelvic pain syndrome (UCPPS) may be defined to include interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The hallmark symptom of UCPPS is chronic pain in the pelvis, urogenital floor, or external genitalia often accompanied by lower urinary tract symptoms. Despite numerous past basic and clinical research studies there is no broadly identifiable organ-specific pathology or understanding of etiology or risk factors for UCPPS, and diagnosis relies primarily on patient reported symptoms. In addition, there are no generally effective therapies. Recent findings have, however, revealed associations between UCPPS and "centralized" chronic pain disorders, suggesting UCPPS may represent a local manifestation of more widespread pathology in some patients. Here, we describe a new and novel effort initiated by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the U.S. National Institutes of Health (NIH) to address the many long standing questions regarding UCPPS, the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. The MAPP Network approaches UCPPS in a systemic manner, in which the interplay between the genitourinary system and other physiological systems is emphasized. The network's study design expands beyond previous research, which has primarily focused on urologic organs and tissues, to utilize integrated approaches to define patient phenotypes, identify clinically-relevant subgroups, and better understand treated natural history and pathophysiology. Thus, the MAPP Network provides an unprecedented, multi-layered characterization of UCPPS. Knowledge gained is expected to provide important insights into underlying pathophysiology, a foundation for better segmenting patients for future clinical trials, and ultimately translation into improved clinical management. In addition, the MAPP Network's integrated multi-disciplinary research approach may serve as a model for studies of urologic and non-urologic disorders that have proven refractory to past basic and clinical study.

Original languageEnglish (US)
Article number57
JournalBMC Urology
Volume14
Issue number1
DOIs
StatePublished - Aug 1 2014

Fingerprint

Pelvic Pain
Chronic Pain
Research
Interstitial Cystitis
Prostatitis
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Pathology
Urogenital System
Lower Urinary Tract Symptoms
Somatoform Disorders
Genitalia
National Institutes of Health (U.S.)
Natural History
Pelvis

Keywords

  • Chronic prostatitis
  • Interstitial cystitis
  • Multi-disciplinary
  • Translational research
  • Urological chronic pelvic pain syndromes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

Cite this

The MAPP Research Network Study Group. / The MAPP research network : A novel study of urologic chronic pelvic pain syndromes. In: BMC Urology. 2014 ; Vol. 14, No. 1.
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title = "The MAPP research network: A novel study of urologic chronic pelvic pain syndromes",
abstract = "Trial registration. ClinicalTrials.gov identifier: NCT01098279 {"}Chronic Pelvic Pain Study of Individuals with Diagnoses or Symptoms of Interstitial Cystitis and/or Chronic Prostatitis (MAPP-EP){"}.Urologic chronic pelvic pain syndrome (UCPPS) may be defined to include interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The hallmark symptom of UCPPS is chronic pain in the pelvis, urogenital floor, or external genitalia often accompanied by lower urinary tract symptoms. Despite numerous past basic and clinical research studies there is no broadly identifiable organ-specific pathology or understanding of etiology or risk factors for UCPPS, and diagnosis relies primarily on patient reported symptoms. In addition, there are no generally effective therapies. Recent findings have, however, revealed associations between UCPPS and {"}centralized{"} chronic pain disorders, suggesting UCPPS may represent a local manifestation of more widespread pathology in some patients. Here, we describe a new and novel effort initiated by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the U.S. National Institutes of Health (NIH) to address the many long standing questions regarding UCPPS, the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. The MAPP Network approaches UCPPS in a systemic manner, in which the interplay between the genitourinary system and other physiological systems is emphasized. The network's study design expands beyond previous research, which has primarily focused on urologic organs and tissues, to utilize integrated approaches to define patient phenotypes, identify clinically-relevant subgroups, and better understand treated natural history and pathophysiology. Thus, the MAPP Network provides an unprecedented, multi-layered characterization of UCPPS. Knowledge gained is expected to provide important insights into underlying pathophysiology, a foundation for better segmenting patients for future clinical trials, and ultimately translation into improved clinical management. In addition, the MAPP Network's integrated multi-disciplinary research approach may serve as a model for studies of urologic and non-urologic disorders that have proven refractory to past basic and clinical study.",
keywords = "Chronic prostatitis, Interstitial cystitis, Multi-disciplinary, Translational research, Urological chronic pelvic pain syndromes",
author = "{The MAPP Research Network Study Group} and Clemens, {J. Quentin} and Chris Mullins and Kusek, {John W.} and Ziya Kirkali and Mayer, {Emeran A.} and Rodr{\'i}guez, {Larissa V.} and Klumpp, {David J.} and Schaeffer, {Anthony J.} and Kreder, {Karl J.} and Dedra Buchwald and Andriole, {Gerald L.} and Lucia, {M. Scott} and Landis, {J. Richard} and Clauw, {Daniel J.} and Philip Hanno and Pontari, {Michel A.} and David Cella and Farmer, {Melissa A.} and Colleen Fitzgerald and Richard Gershon and Griffith, {James W.} and Heckman, {Charles J.} and Mingchen Jiang and Laurie Keefer and Marko, {Darlene S.} and Jean Michniewicz and Todd Parrish and Frank Tu and Jeffry Alger and Ashe-McNalley, {Cody P.} and Ben Ellingson and Nuwanthi Heendeniya and Lisa Kilpatrick and Jason Kutch and Labus, {Jennifer S.} and Naliboff, {Bruce D.} and Fornessa Randal and Smith, {Suzanne R.} and Bradley, {Catherine S.} and Mary Eno and Kris Greiner and Yi Luo and Lutgendorf, {Susan K.} and O'Donnell, {Michael A.} and Barbara Ziegler and Suzie As-Sanie and Sandra Berry and Halvorson, {Megan E.} and Richard Harris",
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The MAPP research network : A novel study of urologic chronic pelvic pain syndromes. / The MAPP Research Network Study Group.

In: BMC Urology, Vol. 14, No. 1, 57, 01.08.2014.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The MAPP research network

T2 - A novel study of urologic chronic pelvic pain syndromes

AU - The MAPP Research Network Study Group

AU - Clemens, J. Quentin

AU - Mullins, Chris

AU - Kusek, John W.

AU - Kirkali, Ziya

AU - Mayer, Emeran A.

AU - Rodríguez, Larissa V.

AU - Klumpp, David J.

AU - Schaeffer, Anthony J.

AU - Kreder, Karl J.

AU - Buchwald, Dedra

AU - Andriole, Gerald L.

AU - Lucia, M. Scott

AU - Landis, J. Richard

AU - Clauw, Daniel J.

AU - Hanno, Philip

AU - Pontari, Michel A.

AU - Cella, David

AU - Farmer, Melissa A.

AU - Fitzgerald, Colleen

AU - Gershon, Richard

AU - Griffith, James W.

AU - Heckman, Charles J.

AU - Jiang, Mingchen

AU - Keefer, Laurie

AU - Marko, Darlene S.

AU - Michniewicz, Jean

AU - Parrish, Todd

AU - Tu, Frank

AU - Alger, Jeffry

AU - Ashe-McNalley, Cody P.

AU - Ellingson, Ben

AU - Heendeniya, Nuwanthi

AU - Kilpatrick, Lisa

AU - Kutch, Jason

AU - Labus, Jennifer S.

AU - Naliboff, Bruce D.

AU - Randal, Fornessa

AU - Smith, Suzanne R.

AU - Bradley, Catherine S.

AU - Eno, Mary

AU - Greiner, Kris

AU - Luo, Yi

AU - Lutgendorf, Susan K.

AU - O'Donnell, Michael A.

AU - Ziegler, Barbara

AU - As-Sanie, Suzie

AU - Berry, Sandra

AU - Halvorson, Megan E.

AU - Harris, Richard

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Trial registration. ClinicalTrials.gov identifier: NCT01098279 "Chronic Pelvic Pain Study of Individuals with Diagnoses or Symptoms of Interstitial Cystitis and/or Chronic Prostatitis (MAPP-EP)".Urologic chronic pelvic pain syndrome (UCPPS) may be defined to include interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The hallmark symptom of UCPPS is chronic pain in the pelvis, urogenital floor, or external genitalia often accompanied by lower urinary tract symptoms. Despite numerous past basic and clinical research studies there is no broadly identifiable organ-specific pathology or understanding of etiology or risk factors for UCPPS, and diagnosis relies primarily on patient reported symptoms. In addition, there are no generally effective therapies. Recent findings have, however, revealed associations between UCPPS and "centralized" chronic pain disorders, suggesting UCPPS may represent a local manifestation of more widespread pathology in some patients. Here, we describe a new and novel effort initiated by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the U.S. National Institutes of Health (NIH) to address the many long standing questions regarding UCPPS, the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. The MAPP Network approaches UCPPS in a systemic manner, in which the interplay between the genitourinary system and other physiological systems is emphasized. The network's study design expands beyond previous research, which has primarily focused on urologic organs and tissues, to utilize integrated approaches to define patient phenotypes, identify clinically-relevant subgroups, and better understand treated natural history and pathophysiology. Thus, the MAPP Network provides an unprecedented, multi-layered characterization of UCPPS. Knowledge gained is expected to provide important insights into underlying pathophysiology, a foundation for better segmenting patients for future clinical trials, and ultimately translation into improved clinical management. In addition, the MAPP Network's integrated multi-disciplinary research approach may serve as a model for studies of urologic and non-urologic disorders that have proven refractory to past basic and clinical study.

AB - Trial registration. ClinicalTrials.gov identifier: NCT01098279 "Chronic Pelvic Pain Study of Individuals with Diagnoses or Symptoms of Interstitial Cystitis and/or Chronic Prostatitis (MAPP-EP)".Urologic chronic pelvic pain syndrome (UCPPS) may be defined to include interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The hallmark symptom of UCPPS is chronic pain in the pelvis, urogenital floor, or external genitalia often accompanied by lower urinary tract symptoms. Despite numerous past basic and clinical research studies there is no broadly identifiable organ-specific pathology or understanding of etiology or risk factors for UCPPS, and diagnosis relies primarily on patient reported symptoms. In addition, there are no generally effective therapies. Recent findings have, however, revealed associations between UCPPS and "centralized" chronic pain disorders, suggesting UCPPS may represent a local manifestation of more widespread pathology in some patients. Here, we describe a new and novel effort initiated by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the U.S. National Institutes of Health (NIH) to address the many long standing questions regarding UCPPS, the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. The MAPP Network approaches UCPPS in a systemic manner, in which the interplay between the genitourinary system and other physiological systems is emphasized. The network's study design expands beyond previous research, which has primarily focused on urologic organs and tissues, to utilize integrated approaches to define patient phenotypes, identify clinically-relevant subgroups, and better understand treated natural history and pathophysiology. Thus, the MAPP Network provides an unprecedented, multi-layered characterization of UCPPS. Knowledge gained is expected to provide important insights into underlying pathophysiology, a foundation for better segmenting patients for future clinical trials, and ultimately translation into improved clinical management. In addition, the MAPP Network's integrated multi-disciplinary research approach may serve as a model for studies of urologic and non-urologic disorders that have proven refractory to past basic and clinical study.

KW - Chronic prostatitis

KW - Interstitial cystitis

KW - Multi-disciplinary

KW - Translational research

KW - Urological chronic pelvic pain syndromes

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DO - 10.1186/1471-2490-14-57

M3 - Review article

VL - 14

JO - BMC Urology

JF - BMC Urology

SN - 1471-2490

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