The mechanical basis of impaired esophageal emptying postfundoplication

Sudip K. Ghosh, Peter J. Kahrilas, Tamer Zaki, John E. Pandolfino, Raymond J. Joehl, James G. Brasseur*

*Corresponding author for this work

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Fundoplication (FP) efficacy is a trade-off between protection against reflux and postoperative dysphagia from the surgically altered mechanical balance within the esophagogastric segment. The purpose of the study was to contrast quantitatively the mechanical balance between normal and post-FP esophageal emptying. Physiological data were combined with mathematical models based on the laws of mechanics. Seven normal controls (NC) and seven post-FP patients underwent concurrent manometry and fluoroscopy. Temporal changes in geometry of the distal bolus cavity and hiatal canal, and cavity-driving pressure were quantified during emptying. Mathematical models were developed to couple cavity pressure to hiatal geometry and esophageal emptying and to determine cavity muscle tone. We found that the average length of the hiatal canal post-FP was twice that of NC; reduction of hiatal radius was not significant. All esophageal emptying events post-FP were incomplete (51% retention); there was no significant difference in the period of emptying between NC and post-FP, and average emptying rates were 40% lower post-FP. The model predicted three distinct phases during esophageal emptying: hiatal opening (phase I), a quasi-steady period (phase II), and final emptying (phase III). A rapid increase in muscle tone and driving pressure forced normal hiatal opening. Post-FP there was a severe impairment of cavity muscle tone causing deficient hiatal opening and flow and bolus retention. We conclude that impaired esophageal emptying post-FP follows from the inability of distal esophageal muscle to generate necessary tone rapidly. Immobilization of the intrinsic sphincter by the surgical procedure may contribute to this deficiency, impaired emptying, and possibly, dysphagia.

Original languageEnglish (US)
Pages (from-to)G21-G35
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume289
Issue number1 52-1
DOIs
StatePublished - Jul 1 2005

Keywords

  • Dysphagia
  • Gastroesophageal reflux disease
  • Lower esophageal sphincter
  • Mathematical model
  • Tone

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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