The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer

Keyphrases

• Apoptosis-inducing Activity 20%
• Breast Cancer 100%
• Breast Cancer Cells 20%
• Cancer Stemness 100%
• Canonical Component 20%
• Caspase 40%
• Caspase-2 20%
• Caspase-8 20%
• CD95 100%
• Chronic Stimulation 20%
• Complex Cell 20%
• Death Receptor 20%
• Death-inducing Signaling Complex 20%
• Double-stranded RNA 20%
• Endogenous Retrovirus 20%
• Gene Regulatory Network 20%
• IFN-I 40%
• Immune Components 20%
• Innate Immune Response 20%
• Melanoma Differentiation-associated Gene 5 (MDA5) 20%
• NF-B 20%
• Non-apoptotic Functions 20%
• Non-cell Autonomous 20%
• Retinoic Acid-inducible Gene I (RIG-I) 20%
• RNA Sensors 20%
• Sensor Protein 20%
• STAT1 Pathway 20%
• STAT2 20%
• Therapy Resistance 20%
• Type I IFN 100%
• Type I Interferon 20%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 33%
• Caspase 66%
• Caspase 2 33%
• Caspase 8 33%
• Death-Inducing Signaling Complex 33%
• Double-Stranded RNA 33%
• Endogenous Retrovirus 33%
• FADD 33%
• Interferon Type I 33%
• MDA5 33%
• Programmed Cell Death 33%
• Regulatory Network 33%
• RIG-I 33%
• STAT1 100%
• STAT2 33%
• Upregulation 33%