The mechanism of phospholipase C-γ1 regulation

Myung Jong Kim, Euikyung Kim, Sung Ho Ryu, Pann Ghill Sun

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-γ1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-γ1.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalExperimental and Molecular Medicine
Volume32
Issue number3
DOIs
StatePublished - Sep 30 2000

Keywords

  • Phospholipase C
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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