The mechanism of phospholipase C-γ1 regulation

Myung Jong Kim; Euikyung Kim; Sung Ho Ryu; Pann Ghill Sun

doi:10.1038/emm.2000.18

The mechanism of phospholipase C-γ1 regulation

Myung Jong Kim, Euikyung Kim, Sung Ho Ryu, Pann Ghill Sun

Neurology

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

Phospholipase C (PLC)¹ hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP₃) and diacylglycerol (DAG). IP₃ induces a transient increase in intracellular free Ca²⁺, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-γ1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-γ1.

Original language	English (US)
Pages (from-to)	101-109
Number of pages	9
Journal	Experimental and Molecular Medicine
Volume	32
Issue number	3
DOIs	https://doi.org/10.1038/emm.2000.18
State	Published - Sep 30 2000

Keywords

Phospholipase C
Protein kinase C

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

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10.1038/emm.2000.18

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title = "The mechanism of phospholipase C-γ1 regulation",

abstract = "Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-γ1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-γ1.",

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N2 - Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-γ1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-γ1.

AB - Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-γ1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-γ1.

KW - Phospholipase C

KW - Protein kinase C

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The mechanism of phospholipase C-γ1 regulation

Abstract

Keywords

ASJC Scopus subject areas

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