The mechanism of tissue welding using a green laser: Revisited

Claus-Peter Richter, R. Bellam, E. Hezarkhani, T. Fiebig

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A "green" laser (e.g. Nd:YAG, λ = 532 nm) together with the red dye Rose Bengal (RB) have been used for photochemical tissue bonding (PTB). It has been reported that irradiation of RB with light at 532 nm produces free radicals. For tissue bonding with a Nd:YAG laser it has been proposed that the free radicals than crosslink the tissue collagen and lead to the closing of the surgical incisions. RB is also a red solution and it is possible that RB absorbs the photons delivered from the laser and converts them into heat with a measurable local temperature increase. It is possible that the mechanism for PTB is not only caused by free radical formation but also by a temperature increase in the tissue. In the present study we measured the local tissue temperature with a micro thermometer during irradiation with a Nd:YAG laser before and after RB was applied. For the present laser settings "tissue painting" with RB lead to a temperature increase resulting in tissue coagulation and charring. PTB was also studied for RB with a free radical scavenger, vitamin C. No significant difference in bonding strength was found for RB alone and for RB together with a free radical scavenger. In case no RB was applied no tissue bonding occurred. Bonding strength was quantified using the leakage seal test.

Original languageEnglish (US)
Title of host publicationOptical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology
EditorsKrzysztof Izdebski, Justus F. Ilgner, Brian J. F. Wong
PublisherSPIE
Volume10039
ISBN (Electronic)9781510605190
DOIs
StatePublished - Jan 1 2017
EventOptical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology - San Francisco, United States
Duration: Jan 28 2017Jan 29 2017

Other

OtherOptical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology
CountryUnited States
CitySan Francisco
Period1/28/171/29/17

Keywords

  • Laser welding
  • Rose Bengal
  • heat
  • photochemical bonding
  • porcine skin

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Richter, C-P., Bellam, R., Hezarkhani, E., & Fiebig, T. (2017). The mechanism of tissue welding using a green laser: Revisited. In K. Izdebski, J. F. Ilgner, & B. J. F. Wong (Eds.), Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology (Vol. 10039). [100390N] SPIE. https://doi.org/10.1117/12.2253260