The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase

Navin Viswakarma, Yuzhi Jia, Liang Bai, Qian Gao, Bingliang Lin, Xiaohong Zhang, Parimal Misra, Ajay Rana, Sanjay Jain, Frank J. Gonzalez, Yi Jun Zhu, Bayar Thimmapaya, Janardan K. Reddy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: The Med1 subunit of the Mediator complex orchestrates metabolic pathways of energy metabolism. Results: Overexpression of Med1 in liver enhances hepatocyte proliferation and the cellular energy sensor AMPK phosphorylates Med1. Conclusion: Med1 is essential for hepatocellular proliferation and energy homeostasis downstream to AMPK. Significance: Med1 and its phosphorylation by AMPK may have important implications in the pathophysiology of liver.

Original languageEnglish (US)
Pages (from-to)27898-27911
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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