The metal centres of particulate methane mono-oxygenase

Amy C. Rosenzweig*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


pMMO (particulate methane mono-oxygenase) is an integral membrane metalloenzyme that catalyses the oxidation of methane to methanol. The pMMO metal active site has not been identified, precluding detailed investigation of the reaction mechanism. Models for the metal centres proposed by various research groups have evolved as crystallographic and spectroscopic data have become available. The present review traces the evolution of these active-site models before and after the 2005 Methylococcus capsulatus (Bath) pMMO crystal structure determination.

Original languageEnglish (US)
Pages (from-to)1134-1137
Number of pages4
JournalBiochemical Society transactions
Issue number6
StatePublished - 2008


  • Copper
  • Crystal structure
  • Iron
  • Metalloenzyme
  • Methane mono-oxygenase
  • Methane oxidation

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'The metal centres of particulate methane mono-oxygenase'. Together they form a unique fingerprint.

Cite this