Abstract
INTRODUCTION: Endoscopy, standard-of-care for monitoring eosinophilic esophagitis (EoE), assesses mucosal inflammation. The Esophageal String Test (EST), a minimally invasive swallowed capsule and immunoassays, quantifies EoE inflammation. We determined whether the EST/EoEScore can monitor disease in patients undergoing treatment. METHODS: Thirty-three samples from 14 patients with EoE (7 children, 7 adults) who underwent repeat endoscopies and ESTs were studied. Biopsies were analyzed for peak eosinophil counts; ESTs were analyzed for EoEScores. RESULTS: Eosinophil counts and EoEScores significantly correlated during treatment, distinguishing patients with active EoE from treatment-associated remissions for 93.9% of ESTs performed. DISCUSSION: The EST can be used to longitudinally monitor responses to treatment in EoE.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 254-258 |
| Number of pages | 5 |
| Journal | American Journal of Gastroenterology |
| Volume | 120 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2025 |
Funding
The authors thank the patients and families who participated in this study by performing repeat ESTs, the gastroenterology physicians and pathologists who performed endoscopic and biopsy assessments, and the nurses and research coordinators at participating sites without whom the study would not have been possible. This study was funded by FDA grant R01FD004086 (to SJA/GTF), awarded through the RFA-FD-11-001 \u201CClinical Studies of Safety and Effectiveness of Orphan Products Research Project Grants (R01)\u201D. The study sponsors have not had any role in the study design, collection, analysis, or interpretation of the data, nor in the writing of this report.
Keywords
- adult
- biomarkers
- eosinophilic esophagitis
- monitoring
- mucosal inflammation
- pediatric
- string test
ASJC Scopus subject areas
- Hepatology
- Gastroenterology