The MOGE(S) classification of cardiomyopathy for clinicians

Eloisa Arbustini, Navneet Narula, Luigi Tavazzi, Alessandra Serio, Maurizia Grasso, Valentina Favalli, Riccardo Bellazzi, Jamil A. Tajik, Robert D. Bonow, Valentin Fuster, Jagat Narula*

*Corresponding author for this work

Research output: Contribution to journalReview article

81 Scopus citations

Abstract

Most cardiomyopathies are familial diseases. Cascade family screening identifies asymptomatic patients and family members with early traits of disease. The inheritance is autosomal dominant in a majority of cases, and recessive, X-linked, or matrilinear in the remaining. For the last 50 years, cardiomyopathy classifications have been based on the morphofunctional phenotypes, allowing cardiologists to conveniently group them in broad descriptive categories. However, the phenotype may not always conform to the genetic characteristics, may not allow risk stratification, and may not provide pre-clinical diagnoses in the family members. Because genetic testing is now increasingly becoming a part of clinical work-up, and based on the genetic heterogeneity, numerous new names are being coined for the description of cardiomyopathies associated with mutations in different genes; a comprehensive nosology is needed that could inform the clinical phenotype and involvement of organs other than the heart, as well as the genotype and the mode of inheritance. The recently proposed MOGE(S) nosology system embodies all of these characteristics, and describes the morphofunctional phenotype (M), organ(s) involvement (O), genetic inheritance pattern (G), etiological annotation (E) including genetic defect or underlying disease/substrate, and the functional status (S) of the disease using both the American College of Cardiology/American Heart Association stage and New York Heart Association functional class. The proposed nomenclature is supported by a web-assisted application and assists in the description of cardiomyopathy in symptomatic or asymptomatic patients and family members in the context of genetic testing. It is expected that such a nomenclature would help group cardiomyopathies on their etiological basis, describe complex genetics, and create collaborative registries.

Original languageEnglish (US)
Pages (from-to)304-318
Number of pages15
JournalJournal of the American College of Cardiology
Volume64
Issue number3
DOIs
StatePublished - Jul 22 2014

Keywords

  • cardiomyopathy
  • classification
  • genetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Arbustini, E., Narula, N., Tavazzi, L., Serio, A., Grasso, M., Favalli, V., Bellazzi, R., Tajik, J. A., Bonow, R. D., Fuster, V., & Narula, J. (2014). The MOGE(S) classification of cardiomyopathy for clinicians. Journal of the American College of Cardiology, 64(3), 304-318. https://doi.org/10.1016/j.jacc.2014.05.027