TY - JOUR
T1 - The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
AU - Fang, Xuexian
AU - Ardehali, Hossein
AU - Min, Junxia
AU - Wang, Fudi
N1 - Funding Information:
The authors receive support from the National Natural Science Foundation of China (82170644 and 31900835 to X.F., 31970689 to J.M. and 31930057 to F.W.), the National Key R&D Program (2018YFA0507801 to J.M. and 2018YFA0507802 to F.W.), the Zhejiang Provincial Natural Science Foundation of China (Y22C115257 to X.F.), the NIH (grants NHLBI HL127646, HL140973, R01 HL140927 and HL138982 to H.A.) and the Leducq Foundation (to H.A.). The authors thank L. Luo (Guangdong Medical University, China) for helping to draft the figures before submission. The authors thank X. Bi, X. Yang and Y. Yu (Zhejiang University School of Medicine, China) for their contribution to the discussion of this Review and apologize to their colleagues whose valuable contributions are not cited in this manuscript owing to space limitations.
Funding Information:
The authors receive support from the National Natural Science Foundation of China (82170644 and 31900835 to X.F., 31970689 to J.M. and 31930057 to F.W.), the National Key R&D Program (2018YFA0507801 to J.M. and 2018YFA0507802 to F.W.), the Zhejiang Provincial Natural Science Foundation of China (Y22C115257 to X.F.), the NIH (grants NHLBI HL127646, HL140973, R01 HL140927 and HL138982 to H.A.) and the Leducq Foundation (to H.A.). The authors thank L. Luo (Guangdong Medical University, China) for helping to draft the figures before submission. The authors thank X. Bi, X. Yang and Y. Yu (Zhejiang University School of Medicine, China) for their contribution to the discussion of this Review and apologize to their colleagues whose valuable contributions are not cited in this manuscript owing to space limitations.
Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2023/1
Y1 - 2023/1
N2 - The maintenance of iron homeostasis is essential for proper cardiac function. A growing body of evidence suggests that iron imbalance is the common denominator in many subtypes of cardiovascular disease. In the past 10 years, ferroptosis, an iron-dependent form of regulated cell death, has become increasingly recognized as an important process that mediates the pathogenesis and progression of numerous cardiovascular diseases, including atherosclerosis, drug-induced heart failure, myocardial ischaemia–reperfusion injury, sepsis-induced cardiomyopathy, arrhythmia and diabetic cardiomyopathy. Therefore, a thorough understanding of the mechanisms involved in the regulation of iron metabolism and ferroptosis in cardiomyocytes might lead to improvements in disease management. In this Review, we summarize the relationship between the metabolic and molecular pathways of iron signalling and ferroptosis in the context of cardiovascular disease. We also discuss the potential targets of ferroptosis in the treatment of cardiovascular disease and describe the current limitations and future directions of these novel treatment targets.
AB - The maintenance of iron homeostasis is essential for proper cardiac function. A growing body of evidence suggests that iron imbalance is the common denominator in many subtypes of cardiovascular disease. In the past 10 years, ferroptosis, an iron-dependent form of regulated cell death, has become increasingly recognized as an important process that mediates the pathogenesis and progression of numerous cardiovascular diseases, including atherosclerosis, drug-induced heart failure, myocardial ischaemia–reperfusion injury, sepsis-induced cardiomyopathy, arrhythmia and diabetic cardiomyopathy. Therefore, a thorough understanding of the mechanisms involved in the regulation of iron metabolism and ferroptosis in cardiomyocytes might lead to improvements in disease management. In this Review, we summarize the relationship between the metabolic and molecular pathways of iron signalling and ferroptosis in the context of cardiovascular disease. We also discuss the potential targets of ferroptosis in the treatment of cardiovascular disease and describe the current limitations and future directions of these novel treatment targets.
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U2 - 10.1038/s41569-022-00735-4
DO - 10.1038/s41569-022-00735-4
M3 - Review article
C2 - 35788564
AN - SCOPUS:85133487973
VL - 20
SP - 7
EP - 23
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
SN - 1759-5002
IS - 1
ER -
