The molecular basis of DNA-protein recognition inferred from the structure of cro repressor

D. H. Ohlendorf*, W. F. Anderson, R. G. Fisher, Y. Takeda, B. W. Matthews

*Corresponding author for this work

Research output: Contribution to journalArticle

182 Scopus citations

Abstract

Recognition by cro repressor protein of its specific DNA binding sites appears to occur via multidentate hydrogen bonds between amino acid side chains of the protein and base-pair atoms in the major groove of right-handed B-form DNA. Most of the sequence-specific interactions between cro and DNA, as well as a number of sequence-independent ones, are mediated by a two-α-helical unit which appears to be common to many proteins that regulate gene expression.

Original languageEnglish (US)
Pages (from-to)718-723
Number of pages6
JournalNature
Volume298
Issue number5876
DOIs
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • General

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