The mucosal barrier, IgE-mediated gastrointestinal events, and eosinophilic gastroenteritis

B. K. Wershil*, W. A. Walker

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The 'mucosal barrier' plays an important role in regulating immune responses in the gastrointestinal tract. Although the precise mechanisms controlling mucosal immune responses have not been defined, when an abnormal response such as IgE production is initiated, a variety of complex and incompletely understood pathophysiologic events occur and can result in gastrointestinal pathology. This article attempts to present the complexity of such abnormal responses. Although more questions have emerged than were answered, in recent years our knowledge of the pathophysiology of IgE- mediated events in the gastrointestinal tract has advanced significantly. Our understanding of the pathophysiology of these events will ultimately allow the development of more directed and effective therapeutic interventions for allergic gastrointestinal diseases. In addition, through further clinical and basic research, we should begin to unravel the more enigmatic conditions affecting the gastrointestinal tract, such as EG.

Original languageEnglish (US)
Pages (from-to)387-404
Number of pages18
JournalGastroenterology Clinics of North America
Issue number2
StatePublished - 1992

ASJC Scopus subject areas

  • Gastroenterology


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