The multidisciplinary management of giant cell tumor of bone

Vincent Y. Ng, Darin J. Davidson, Edward Y. Kim, Seth M. Pollack, Ernest U. Conrad, Robin L. Jones*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Giant cell tumor of bone is a locally aggressive lesion with a predilection for local recurrence, and in a small proportion of patients, metastatic disease can develop. Surgery is the mainstay of management for extremity-based lesions. For tumors located in challenging anatomical locations such as the sacrum and spine however, surgery may be associated with unacceptable functional morbidity. There are limited data regarding other treatment modalities such as radiation therapy, cytotoxic chemotherapy, interferon and bisphosphonates. Serial arterial embolization can be effective in some cases. Recent evidence has demonstrated denosumab to be a promising agent in the treatment of unresectable or metastatic disease.

Original languageEnglish (US)
Pages (from-to)783-790
Number of pages8
JournalExpert review of anticancer therapy
Volume14
Issue number7
DOIs
StatePublished - Jul 2014
Externally publishedYes

Keywords

  • Denosumab
  • Giant cell
  • Management
  • Multi modality
  • Osteoclast
  • Receptor activator of nuclear factor κ-B
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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