The multifunctional nature of mitochondrial contact site proteins

Clare S. Harper, Antoineen J. White, Laura L. Lackner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial contact sites has been gained. In doing so, it has become clear that one protein or protein complex can contribute to contact site formation and function in a wide variety of ways. Thus, complex and often surprising relationships between the roles of a mitochondrial contact site and its multifunctional resident proteins continue to be unraveled.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalCurrent Opinion in Cell Biology
StatePublished - Aug 2020


  • Membrane contact sites
  • Mitochondria
  • Mitochondrial contact sites

ASJC Scopus subject areas

  • Cell Biology


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