The murine T-cell receptor uses a limited repertoire of expressed V β gene segments

Richard K. Barth; Byung S. Kim; Nancy C. Lan; Tim Hunkapiller; Nancy Sobieck; Astar Winoto; Howard Gershenfeld; Craig Okada; Dan Hansburg; Irving L. Weissman; Leroy Hood

doi:10.1038/316517a0

The murine T-cell receptor uses a limited repertoire of expressed V _β gene segments

Richard K. Barth^*, Byung S. Kim, Nancy C. Lan, Tim Hunkapiller, Nancy Sobieck, Astar Winoto, Howard Gershenfeld, Craig Okada, Dan Hansburg, Irving L. Weissman, Leroy Hood

^*Corresponding author for this work

Microbiology-Immunology

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247 Scopus citations

Abstract

Only 10 different V_β gene segments were found when the sequences of 15 variable (V_β) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V_β gene segments may be 21 or fewer, which makes the expressed germline V_β repertoire much smaller than that of the immunoglobulin heavy-chain or light-chain genes. We suggest that βchain somatic diversification is concentrated at the V_β-D _β-J_β junctions.

Original language	English (US)
Pages (from-to)	517-523
Number of pages	7
Journal	Nature
Volume	316
Issue number	6028
DOIs	https://doi.org/10.1038/316517a0
State	Published - 1985

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title = "The murine T-cell receptor uses a limited repertoire of expressed V β gene segments",

abstract = "Only 10 different Vβ gene segments were found when the sequences of 15 variable (Vβ) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed Vβ gene segments may be 21 or fewer, which makes the expressed germline Vβ repertoire much smaller than that of the immunoglobulin heavy-chain or light-chain genes. We suggest that βchain somatic diversification is concentrated at the Vβ-D β-Jβ junctions.",

author = "Barth, {Richard K.} and Kim, {Byung S.} and Lan, {Nancy C.} and Tim Hunkapiller and Nancy Sobieck and Astar Winoto and Howard Gershenfeld and Craig Okada and Dan Hansburg and Weissman, {Irving L.} and Leroy Hood",

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doi = "10.1038/316517a0",

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T1 - The murine T-cell receptor uses a limited repertoire of expressed V β gene segments

AU - Barth, Richard K.

AU - Kim, Byung S.

AU - Lan, Nancy C.

AU - Hunkapiller, Tim

AU - Sobieck, Nancy

AU - Winoto, Astar

AU - Gershenfeld, Howard

AU - Okada, Craig

AU - Hansburg, Dan

AU - Weissman, Irving L.

AU - Hood, Leroy

PY - 1985

Y1 - 1985

N2 - Only 10 different Vβ gene segments were found when the sequences of 15 variable (Vβ) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed Vβ gene segments may be 21 or fewer, which makes the expressed germline Vβ repertoire much smaller than that of the immunoglobulin heavy-chain or light-chain genes. We suggest that βchain somatic diversification is concentrated at the Vβ-D β-Jβ junctions.

AB - Only 10 different Vβ gene segments were found when the sequences of 15 variable (Vβ) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed Vβ gene segments may be 21 or fewer, which makes the expressed germline Vβ repertoire much smaller than that of the immunoglobulin heavy-chain or light-chain genes. We suggest that βchain somatic diversification is concentrated at the Vβ-D β-Jβ junctions.

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SP - 517

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JO - Nature

JF - Nature

IS - 6028

ER -

The murine T-cell receptor uses a limited repertoire of expressed V _β gene segments

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