Abstract
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intimamedia thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
| Original language | English (US) |
|---|---|
| Article number | eaau8650 |
| Journal | Science |
| Volume | 364 |
| Issue number | 6436 |
| DOIs | |
| State | Published - Jan 1 2019 |
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The NASA twins study : A multidimensional analysis of a year-long human spaceflight. / Garrett-Bakelman, Francine E.; Darshi, Manjula; Green, Stefan J.; Gur, Ruben C.; Lin, Ling; Macias, Brandon R.; McKenna, Miles J.; Meydan, Cem; Mishra, Tejaswini; Nasrini, Jad; Piening, Brian D.; Rizzardi, Lindsay F.; Sharma, Kumar; Siamwala, Jamila H.; Taylor, Lynn; Vitaterna, Martha Hotz; Afkarian, Maryam; Afshinnekoo, Ebrahim; Ahadi, Sara; Ambati, Aditya; Arya, Maneesh; Bezdan, Daniela; Callahan, Colin M.; Chen, Songjie; Choi, Augustine M.K.; Chlipala, George E.; Contrepois, Kévin; Covington, Marisa; Crucian, Brian E.; De Vivo, Immaculata; Dinges, David F.; Ebert, Douglas J.; Feinberg, Jason I.; Gandara, Jorge A.; George, Kerry A.; Goutsias, John; Grills, George S.; Hargens, Alan R.; Heer, Martina; Hillary, Ryan P.; Hoofnagle, Andrew N.; Hook, Vivian Y.H.; Jenkinson, Garrett; Jiang, Peng; Keshavarzian, Ali; Laurie, Steven S.; Lee-McMullen, B.; Lumpkins, Sarah B.; MacKay, Matthew; Maienschein-Cline, Mark G.; Melnick, Ari M.; Moore, Tyler M.; Nakahira, Kiichi; Patel, Hemal H.; Pietrzyk, Robert; Rao, Varsha; Saito, Rintaro; Salins, Denis N.; Schilling, Jan M.; Sears, Dorothy D.; Sheridan, Caroline K.; Stenger, Michael B.; Tryggvadottir, Rakel; Urban, Alexander E.; Vaisar, Tomas; Van Espen, Benjamin; Zhang, Jing; Ziegler, Michael G.; Zwart, Sara R.; Charles, John B.; Kundrot, Craig E.; Scott, Graham B.I.; Bailey, Susan M.; Basner, Mathias; Feinberg, Andrew P.; Lee, Stuart M.C.; Mason, Christopher E.; Mignot, Emmanuel; Rana, Brinda K.; Smith, Scott M.; Snyder, Michael P.; Turek, Fred W.
In: Science, Vol. 364, No. 6436, eaau8650, 01.01.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - The NASA twins study
T2 - A multidimensional analysis of a year-long human spaceflight
AU - Garrett-Bakelman, Francine E.
AU - Darshi, Manjula
AU - Green, Stefan J.
AU - Gur, Ruben C.
AU - Lin, Ling
AU - Macias, Brandon R.
AU - McKenna, Miles J.
AU - Meydan, Cem
AU - Mishra, Tejaswini
AU - Nasrini, Jad
AU - Piening, Brian D.
AU - Rizzardi, Lindsay F.
AU - Sharma, Kumar
AU - Siamwala, Jamila H.
AU - Taylor, Lynn
AU - Vitaterna, Martha Hotz
AU - Afkarian, Maryam
AU - Afshinnekoo, Ebrahim
AU - Ahadi, Sara
AU - Ambati, Aditya
AU - Arya, Maneesh
AU - Bezdan, Daniela
AU - Callahan, Colin M.
AU - Chen, Songjie
AU - Choi, Augustine M.K.
AU - Chlipala, George E.
AU - Contrepois, Kévin
AU - Covington, Marisa
AU - Crucian, Brian E.
AU - De Vivo, Immaculata
AU - Dinges, David F.
AU - Ebert, Douglas J.
AU - Feinberg, Jason I.
AU - Gandara, Jorge A.
AU - George, Kerry A.
AU - Goutsias, John
AU - Grills, George S.
AU - Hargens, Alan R.
AU - Heer, Martina
AU - Hillary, Ryan P.
AU - Hoofnagle, Andrew N.
AU - Hook, Vivian Y.H.
AU - Jenkinson, Garrett
AU - Jiang, Peng
AU - Keshavarzian, Ali
AU - Laurie, Steven S.
AU - Lee-McMullen, B.
AU - Lumpkins, Sarah B.
AU - MacKay, Matthew
AU - Maienschein-Cline, Mark G.
AU - Melnick, Ari M.
AU - Moore, Tyler M.
AU - Nakahira, Kiichi
AU - Patel, Hemal H.
AU - Pietrzyk, Robert
AU - Rao, Varsha
AU - Saito, Rintaro
AU - Salins, Denis N.
AU - Schilling, Jan M.
AU - Sears, Dorothy D.
AU - Sheridan, Caroline K.
AU - Stenger, Michael B.
AU - Tryggvadottir, Rakel
AU - Urban, Alexander E.
AU - Vaisar, Tomas
AU - Van Espen, Benjamin
AU - Zhang, Jing
AU - Ziegler, Michael G.
AU - Zwart, Sara R.
AU - Charles, John B.
AU - Kundrot, Craig E.
AU - Scott, Graham B.I.
AU - Bailey, Susan M.
AU - Basner, Mathias
AU - Feinberg, Andrew P.
AU - Lee, Stuart M.C.
AU - Mason, Christopher E.
AU - Mignot, Emmanuel
AU - Rana, Brinda K.
AU - Smith, Scott M.
AU - Snyder, Michael P.
AU - Turek, Fred W
PY - 2019/1/1
Y1 - 2019/1/1
N2 - To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intimamedia thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
AB - To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intimamedia thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
UR - http://www.scopus.com/inward/record.url?scp=85064686347&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064686347&partnerID=8YFLogxK
U2 - 10.1126/science.aau8650
DO - 10.1126/science.aau8650
M3 - Article
C2 - 30975860
AN - SCOPUS:85064686347
VL - 364
JO - Science
JF - Science
SN - 0036-8075
IS - 6436
M1 - eaau8650
ER -