The nasal crease sign in segmental facial hemangioma - An early sign of cartilage destruction

R. Wright Dakara, C. Russi Daniela, J. Mancini Anthony, L. Chamlin Sarah, M. Wagner Annette*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Although the majority of hemangiomas of infancy do not require treatment, a subset of patients have complications such as ulceration, functional impairment or severe disfigurement that necessitate intervention. It is often difficult to predict which hemangiomas will lead to permanent disfigurement and medical complications. We present three patients with segmental facial hemangiomas involving the nose which resulted in nasal cartilage destruction. All three patients had a linear gray atrophic crease in the inferior columella visualized on clinical examination prior to the onset of nasal collapse. We propose that this "nasal crease sign" in infants with segmental facial hemangioma involving the nose and philtrum may be a premonitory clinical finding of impending nasal cartilage destruction. Dermatologists should be aware of this clinical sign which may help identify patients at high risk of nasal destruction. Unfortunately, aggressive medical intervention may not always prevent devastating disfigurement.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalPediatric dermatology
Issue number3
StatePublished - May 2007

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology


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