The neocortical circuit: Themes and variations

Kenneth D. Harris, Gordon M.G. Shepherd*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

515 Scopus citations


Similarities in neocortical circuit organization across areas and species suggest a common strategy to process diverse types of information, including sensation from diverse modalities, motor control and higher cognitive processes. Cortical neurons belong to a small number of main classes. The properties of these classes, including their local and long-range connectivity, developmental history, gene expression, intrinsic physiology and in vivo activity patterns, are remarkably similar across areas. Each class contains subclasses; for a rapidly growing number of these, conserved patterns of input and output connections are also becoming evident. The ensemble of circuit connections constitutes a basic circuit pattern that appears to be repeated across neocortical areas, with area-and species-specific modifications. Such 'serially homologous' organization may adapt individual neocortical regions to the type of information each must process.

Original languageEnglish (US)
Pages (from-to)170-181
Number of pages12
JournalNature neuroscience
Issue number2
StatePublished - Feb 17 2015

ASJC Scopus subject areas

  • Neuroscience(all)


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