The neuronal response to electrical constant-amplitude pulse train stimulation: Evoked compound action potential recordings

A. J. Matsuoka*, P. J. Abbas, J. T. Rubinstein, C. A. Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The purpose of this study was to gain a greater understanding of the electrically evoked compound action potential (EAP) responses to pulse train stimulation. Analysis of EAP amplitude responses suggested that an alternating pattern varied depending upon stimulus level, interpulse interval (IPI), stimulus waveform, and stimulus polarity. Stimulus level-dependent recovery was seen in the cat and the guinea pig: higher stimulus level tended to provide faster recovery. Both polarity-dependent recovery and polarity-dependent adaptation were observed in the cat and these stimulus polarity effects were less consistent in the guinea pig. The polarity-dependent recovery effect supports the hypothesis that anodal and cathodal stimuli excite different sites along auditory nerve fibers. Amplitude differences between the response to the second pulse and the steady-state response at the same IPI are significantly greater for anodal stimuli than for cathodal stimuli in all cats. These data suggest that there is a cumulative refractory effect in the auditory nerve of cats, especially in response to anodal stimuli. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)115-128
Number of pages14
JournalHearing research
Volume149
Issue number1-2
DOIs
StatePublished - 2000

Keywords

  • Auditory nerve
  • Electrical stimulation
  • Pulse train

ASJC Scopus subject areas

  • Sensory Systems

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