The neuroplasticity-associated Arc gene is a direct transcriptional target of early growth response (Egr) transcription factors

Lin Li, John Carter, Xiaoguang Gao, Jennifer Whitehead, Warren G. Tourtellotte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

Early growth response (Egr) transcription factors (Egr1 to Egr4) are synaptic activity-inducible immediate early genes (IEGs) that regulate some aspects of synaptic plasticity-related to learning and memory, yet the target genes regulated by them are unknown. In particular, Egr1 is essential for persistence of late-phase long-term potentiation (L-LTP), for hippocampus-dependent long-term memory formation, and for reconsolidation of previously established memories. Here, we show that Egr1 and Egr3 directly regulate the plasticity-associated activity-regulated cytoskeletal-related (Arc) gene, a synaptic activity-induced elector molecule which is also required for L-LTP and hippocampus-dependent learning and memory processing. Moreover, Egr1-deficient and Egr3-deficient mice lack Arc protein in a surpopulation of neurons, while mice lacking both Egr1 and Egr3 lack Arc in all neurons. Thus, Egr1 and Egr3 can indirectly modulate synaptic plasticity by directly regulating Arc and the plasticity mechanisms it mediates in recently activated synapses.

Original languageEnglish (US)
Pages (from-to)10286-10300
Number of pages15
JournalMolecular and cellular biology
Volume25
Issue number23
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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