The Newer Fluoroquinolones

Maureen K Bolon*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones-ciprofloxacin, levofloxacin, and moxifloxacin.

Original languageEnglish (US)
Pages (from-to)793-817
Number of pages25
JournalMedical Clinics of North America
Issue number4
StatePublished - Jul 1 2011


  • Antiinfective agents
  • Fluoroquinolones
  • Microbial drug resistance
  • Pharmacokinetics
  • Pharmacology
  • Therapeutic use

ASJC Scopus subject areas

  • General Medicine


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