The Newer Fluoroquinolones

Maureen K Bolon*

*Corresponding author for this work

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones-ciprofloxacin, levofloxacin, and moxifloxacin.

Original languageEnglish (US)
Pages (from-to)793-817
Number of pages25
JournalMedical Clinics of North America
Volume95
Issue number4
DOIs
StatePublished - Jul 1 2011

Fingerprint

Fluoroquinolones
Safety
Levofloxacin
Ciprofloxacin
Streptococcus pneumoniae
Epidemiology
Pharmacology

Keywords

  • Antiinfective agents
  • Fluoroquinolones
  • Microbial drug resistance
  • Pharmacokinetics
  • Pharmacology
  • Therapeutic use

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones-ciprofloxacin, levofloxacin, and moxifloxacin.",
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The Newer Fluoroquinolones. / Bolon, Maureen K.

In: Medical Clinics of North America, Vol. 95, No. 4, 01.07.2011, p. 793-817.

Research output: Contribution to journalReview article

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AU - Bolon, Maureen K

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Y1 - 2011/7/1

N2 - Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones-ciprofloxacin, levofloxacin, and moxifloxacin.

AB - Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones-ciprofloxacin, levofloxacin, and moxifloxacin.

KW - Antiinfective agents

KW - Fluoroquinolones

KW - Microbial drug resistance

KW - Pharmacokinetics

KW - Pharmacology

KW - Therapeutic use

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