The Newer Fluoroquinolones

Maureen K Bolon*

*Corresponding author for this work

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones-ciprofloxacin, levofloxacin, and moxifloxacin.

Original languageEnglish (US)
Pages (from-to)1027-1051
Number of pages25
JournalInfectious Disease Clinics of North America
Volume23
Issue number4
DOIs
Publication statusPublished - Dec 1 2009

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Keywords

  • Antiinfective agents
  • Fluoroquinolones
  • Microbial drug resistance
  • Pharmacokinetics
  • Pharmacology
  • Therapeutic use

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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