The next generation of hemorrhage therapy

Vahagn C. Nikolian, Hasan B. Alam*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The management of major bleeding has significantly improved over the course of time. Patients are no longer relegated to inferior hemorrhage control strategies strictly focused on applying pressure to the wound. Despite these advances, major bleeding remains the most common source of preventable death in both the battlefield and civilian settings. Devices and intervention strategies are continuously being researched and developed to decrease complications and death related to these serious injuries at the trauma scene, in transit, and at higher echelons of care. In addition, further understanding of the pathophysiology of hemorrhage has allowed for the development of novel strategies that work at the cellular and subcellular level to improve outcomes in the setting of massive hemorrhage. This chapter reviews some of the latest developments in hemorrhage therapy and provides perspective on emerging technologies in its management.

Original languageEnglish (US)
Title of host publicationFront Line Surgery
Subtitle of host publicationA Practical Approach
PublisherSpringer International Publishing
Number of pages12
ISBN (Electronic)9783319567808
ISBN (Print)9783319567792
StatePublished - Jul 21 2017
Externally publishedYes


  • Abdominal aortic junctional tourniquet
  • Expandable foam
  • Hemorrhagic shock
  • Hemostatic dressings
  • Hypothermic arrest
  • Junctional tourniquet
  • Pharmacologic resuscitation
  • Plasma protein dressings
  • Suspended animation
  • Valproic acid
  • XStat

ASJC Scopus subject areas

  • General Medicine


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