The nose smells what the eye sees: Crossmodal visual facilitation of human olfactory perception

Jay A. Gottfried*, Raymond J. Dolan

*Corresponding author for this work

Research output: Contribution to journalArticle

338 Scopus citations

Abstract

Human olfactory perception is notoriously unreliable, but shows substantial benefits from visual cues, suggesting important crossmodal integration between these primary sensory modalities. We used event-related fMRI to determine the underlying neural mechanisms of olfactory-visual integration in the human brain. Subjects participated in an olfactory detection task, whereby odors and pictures were delivered separately or together. By manipulating the degree of semantic correspondence between odor-picture pairs, we show a perceptual olfactory facilitation for semantically congruent (versus incongruent) trials. This behavioral advantage was associated with enhanced neural activity in anterior hippocampus and rostromedial orbitofrontal cortex. We suggest these findings can be interpreted as indicating that human hippocampus mediates reactivation of crossmodal semantic associations, even in the absence of explicit memory processing.

Original languageEnglish (US)
Pages (from-to)375-386
Number of pages12
JournalNeuron
Volume39
Issue number2
DOIs
StatePublished - Jul 17 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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