The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-α-expressing cells through caspase-3-mediated cleavage of Mcl-1

INIS

• kinases 100%
• patients 80%
• tyrosine 80%
• proteins 40%
• data 20%
• humans 20%
• solids 20%
• in vitro 20%
• genes 20%
• growth factors 20%
• mutations 20%
• receptors 20%
• inhibition 20%
• death 20%
• phosphorylation 20%
• apoptosis 20%
• proliferation 20%
• cleavage 20%

Biochemistry, Genetics and Molecular Biology

• Tyrosine Kinase Inhibitor 60%
• Imatinib 60%
• Apoptosis 40%
• Development 20%
• Phosphorylation 20%
• Kinase 20%
• down Regulation 20%
• Mutation 20%
• Nested Gene 20%
• STAT3 20%
• Tyrosine Kinase 20%
• Caspase 3 20%
• Caspase 20%
• Methanesulfonic Acid 20%
• Solid 20%
• Platelet-Derived Growth Factor Receptor 20%
• Protein 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Hypereosinophilic Syndrome 80%
• Imatinib 60%
• Protein Tyrosine Kinase Inhibitor 60%
• Caspase 20%
• Caspase 3 20%
• Phosphotransferase 20%
• STAT3 Protein 20%
• Protein Tyrosine Kinase 20%
• Death 20%
• Antiapoptotic 20%
• Platelet Derived Growth Factor Alpha Receptor 20%
• Apoptosis 20%