The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-α-expressing cells through caspase-3-mediated cleavage of Mcl-1

Biochemistry, Genetics and Molecular Biology

• Apoptosis 100%
• Caspase 33%
• Caspase 3 100%
• Development 33%
• down Regulation 33%
• Genetic Code 33%
• Imatinib 100%
• Kinase 33%
• Methanesulfonic Acid 33%
• Mutation 33%
• Nested Gene 33%
• Phosphorylation 33%
• Platelet-Derived Growth Factor Receptor 33%
• Protein 33%
• Solid 33%
• STAT3 33%
• Tyrosine Kinase 33%
• Tyrosine Kinase Inhibitor 100%

INIS

• apoptosis 100%
• cleavage 100%
• data 20%
• death 20%
• genes 20%
• growth factors 20%
• humans 100%
• in vitro 20%
• inhibition 20%
• kinases 100%
• mutations 20%
• patients 80%
• phosphorylation 20%
• proliferation 20%
• proteins 40%
• receptors 20%
• solids 20%
• tyrosine 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Antiapoptotic 25%
• Apoptosis 100%
• Caspase 25%
• Caspase 3 100%
• Death 25%
• Hypereosinophilic Syndrome 100%
• Imatinib 75%
• Phosphotransferase 25%
• Platelet Derived Growth Factor Alpha Receptor 25%
• Protein Tyrosine Kinase 25%
• Protein Tyrosine Kinase Inhibitor 100%
• STAT3 Protein 25%